Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα

The human nuclear xenobiotic receptor PXR recognizes a range of potentially harmful drugs and endobiotic chemicals, but must complex with the nuclear receptor RXRα to control the expression of numerous drug metabolism genes. To date, the structural basis and functional consequences of this interacti...

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Autors principals: Wallace, Bret D., Betts, Laurie, Talmage, Garrick, Pollet, Rebecca M., Holman, Natalie S., Redinbo, Matthew R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699901/
https://ncbi.nlm.nih.gov/pubmed/23602807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.04.012
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