Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

During immune responses, antibodies are selected for their ability to bind to foreign antigens with high affinity, in part by their ability to undergo homotypic bivalent binding. However, this type of binding is not always possible. For example, the small number of gp140 glycoprotein spikes displaye...

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Autori principali: Mouquet, Hugo, Scheid, Johannes F., Zoller, Markus J., Krogsgaard, Michelle, Ott, Rene G., Shukair, Shetha, Artyomov, Maxim N., Pietzsch, John, Connors, Mark, Pereyra, Florencia, Walker, Bruce D., Ho, David D., Wilson, Patrick C., Seaman, Michael S., Eisen, Herman N., Chakraborty, Arup K., Hope, Thomas J., Ravetch, Jeffrey V., Wardemann, Hedda, Nussenzweig, Michel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699875/
https://ncbi.nlm.nih.gov/pubmed/20882016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09385
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