Reversibility of Structural and Functional Damage in a Model of Advanced Diabetic Nephropathy

The reversibility of diabetic nephropathy remains controversial. Here, we tested whether replacing leptin could reverse the advanced diabetic nephropathy modeled by the leptin-deficient BTBR ob/ob mouse. Leptin replacement, but not inhibition of the renin-angiotensin-aldosterone system (RAAS), resul...

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Bibliografiske detaljer
Main Authors: Pichaiwong, Warangkana, Hudkins, Kelly L., Wietecha, Tomasz, Nguyen, Tri Q., Tachaudomdach, Chiraporn, Li, Wei, Askari, Bardia, Kobayashi, Takahisa, O’Brien, Kevin D., Pippin, Jeffrey W., Shankland, Stuart J., Alpers, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2013
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699819/
https://ncbi.nlm.nih.gov/pubmed/23641056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050445
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