Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity

p53 is a transcription factor that mediates tumor suppressor responses. Correct folding of the p53 protein is essential for these activities, and point mutations that induce conformational instability of p53 are frequently found in cancers. These mutant p53s not only lose wild-type activity but can...

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Detaylı Bibliyografya
Asıl Yazarlar: Trinidad, Antonio Garcia, Muller, Patricia A.J., Cuellar, Jorge, Klejnot, Marta, Nobis, Max, Valpuesta, José María, Vousden, Karen H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699784/
https://ncbi.nlm.nih.gov/pubmed/23747015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.002
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