Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity

p53 is a transcription factor that mediates tumor suppressor responses. Correct folding of the p53 protein is essential for these activities, and point mutations that induce conformational instability of p53 are frequently found in cancers. These mutant p53s not only lose wild-type activity but can...

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Autors principals: Trinidad, Antonio Garcia, Muller, Patricia A.J., Cuellar, Jorge, Klejnot, Marta, Nobis, Max, Valpuesta, José María, Vousden, Karen H.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699784/
https://ncbi.nlm.nih.gov/pubmed/23747015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.002
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