Structures of the Gβ-CCT and PhLP1–Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

G-protein signaling depends on the ability of the individual subunits of the G-protein heterotrimer to assemble into a functional complex. Formation of the G-protein βγ (Gβγ) dimer is particularly challenging because it is an obligate dimer in which the individual subunits are unstable on their own....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Plimpton, Rebecca L., Cuéllar, Jorge, Lai, Chun Wan J., Aoba, Takuma, Makaju, Aman, Franklin, Sarah, Mathis, Andrew D., Prince, John T., Carrascosa, José L., Valpuesta, José M., Willardson, Barry M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345582/
https://ncbi.nlm.nih.gov/pubmed/25675501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419595112
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