Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant

A human/plasmodial hybrid enzyme, generated by swapping the human topoisomerase IB linker domain with the corresponding domain of the Plasmodium falciparum enzyme, has been produced and characterized. The hybrid enzyme displays a relaxation activity comparable to the human enzyme, but it is characte...

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Bibliographic Details
Main Authors: Arnò, Barbara, D’Annessa, Ilda, Tesauro, Cinzia, Zuccaro, Laura, Ottaviani, Alessio, Knudsen, Birgitta, Fiorani, Paola, Desideri, Alessandro
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699648/
https://ncbi.nlm.nih.gov/pubmed/23844196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068404
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