Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

BACKGROUND: Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT) and invasion. However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog (Hh) signaling in hypoxia induced pancreatic cancer EMT and invasion. METHODS:...

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Hauptverfasser: Lei, Jianjun, Ma, Jiguang, Ma, Qingyong, Li, Xuqi, Liu, Han, Xu, Qinhong, Duan, Wanxing, Sun, Qing, Xu, Jun, Wu, Zheng, Wu, Erxi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699387/
https://ncbi.nlm.nih.gov/pubmed/23786654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-66
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