Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

BACKGROUND: Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT) and invasion. However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog (Hh) signaling in hypoxia induced pancreatic cancer EMT and invasion. METHODS:...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lei, Jianjun, Ma, Jiguang, Ma, Qingyong, Li, Xuqi, Liu, Han, Xu, Qinhong, Duan, Wanxing, Sun, Qing, Xu, Jun, Wu, Zheng, Wu, Erxi
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699387/
https://ncbi.nlm.nih.gov/pubmed/23786654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-66
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