Pretreatment long interspersed element (LINE)-1 methylation levels, not early hypomethylation under treatment, predict hematological response to azacitidine in elderly patients with acute myeloid leukemia

BACKGROUND: Epigenetic modulations, including changes in DNA cytosine methylation, are implicated in the pathogenesis and progression of acute myeloid leukemia (AML). Azacitidine is a hypomethylating agent that is incorporated into RNA as well as DNA. Thus, there is a rationale to its use in patient...

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Hlavní autoři: Cross, Michael, Bach, Enrica, Tran, Thao, Krahl, Rainer, Jaekel, Nadja, Niederwieser, Dietger, Junghanss, Christian, Maschmeyer, Georg, Al-Ali, Haifa Kathrin
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2013
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699298/
https://ncbi.nlm.nih.gov/pubmed/23836986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S45459
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