Pretreatment long interspersed element (LINE)-1 methylation levels, not early hypomethylation under treatment, predict hematological response to azacitidine in elderly patients with acute myeloid leukemia

BACKGROUND: Epigenetic modulations, including changes in DNA cytosine methylation, are implicated in the pathogenesis and progression of acute myeloid leukemia (AML). Azacitidine is a hypomethylating agent that is incorporated into RNA as well as DNA. Thus, there is a rationale to its use in patient...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cross, Michael, Bach, Enrica, Tran, Thao, Krahl, Rainer, Jaekel, Nadja, Niederwieser, Dietger, Junghanss, Christian, Maschmeyer, Georg, Al-Ali, Haifa Kathrin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Dove Medical Press 2013
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699298/
https://ncbi.nlm.nih.gov/pubmed/23836986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S45459
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak