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Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts

Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions and interspersed shared enhancers. Here, we describe the use of a novel recombineering strategy to introduce simultaneous frameshift mutations into the...

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Autors principals: Raines, Anna M., Adam, Mike, Magella, Bliss, Meyer, Sara E., Grimes, H. Leighton, Dey, Sudhansu K., Potter, S. Steven
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699281/
https://ncbi.nlm.nih.gov/pubmed/23760953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.092569
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