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Mechanism of 2-aminopurine mutagenesis in mouse T-lymphosarcoma cells.

We investigated the mechanism of action of 2-aminopurine (Apur) in eucaryotic cells. By analogy with studies in procaryotic systems, the base analog is presumed to incorporate into DNA predominantly opposite T where, upon subsequent DNA replication, it can mispair with C, inducing an A:T leads to G:...

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Publicat a:Mol Cell Biol
Autors principals: Caras, I W, MacInnes, M A, Persing, D H, Coffino, P, Martin, D W
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1982
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369902/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6983647/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.2.9.1096-1103.1982
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