DNA Priming Prior to Inactivated Influenza A(H5N1) Vaccination Expands the Antibody Epitope Repertoire and Increases Affinity Maturation in a Boost-Interval–Dependent Manner in Adults

DNA priming improves the response to inactivated influenza A(H5N1) vaccination. We compared the immunogenicity of an H5 DNA prime (using strain A/Indonesia/5/2005) followed by an H5N1 monovalent inactivated vaccine boost at 4, 8, 12, 16, or 24 weeks to that of 2 doses of H5N1 monovalent inactivated...

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Main Authors: Khurana, Surender, Wu, Jian, Dimitrova, Milena, King, Lisa R., Manischewitz, Jody, Graham, Barney S., Ledgerwood, Julie E., Golding, Hana
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Major Articles and Brief Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699004/
https://ncbi.nlm.nih.gov/pubmed/23633404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit178
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