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Oral Priming with Replicating Adenovirus Serotype 4 Followed by Subunit H5N1 Vaccine Boost Promotes Antibody Affinity Maturation and Expands H5N1 Cross-Clade Neutralization
A Phase I trial conducted in 2009–2010 demonstrated that oral vaccination with a replication competent Ad4-H5 (A/Vietnam) vector with dosages ranging from 10(7)-10(11) viral particles was well tolerated. HA-specific T-cell responses were efficiently induced, but very limited hemagglutination-inhibit...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4309450/ https://ncbi.nlm.nih.gov/pubmed/25629161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115476 |
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