Oral Priming with Replicating Adenovirus Serotype 4 Followed by Subunit H5N1 Vaccine Boost Promotes Antibody Affinity Maturation and Expands H5N1 Cross-Clade Neutralization

A Phase I trial conducted in 2009–2010 demonstrated that oral vaccination with a replication competent Ad4-H5 (A/Vietnam) vector with dosages ranging from 10(7)-10(11) viral particles was well tolerated. HA-specific T-cell responses were efficiently induced, but very limited hemagglutination-inhibit...

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Опубликовано в: :PLoS One
Главные авторы: Khurana, Surender, Coyle, Elizabeth M., Manischewitz, Jody, King, Lisa R., Ishioka, Glenn, Alexander, Jeff, Smith, Jon, Gurwith, Marc, Golding, Hana
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309450/
https://ncbi.nlm.nih.gov/pubmed/25629161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115476
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