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Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells

The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in constitutive activation of BRAF, which then promotes cell proliferation by the mitogen-activated protein kinase (MAPK) signaling pathway. Although the BRAFV600E kinase inhibitor vemurafenib has remarkable antitu...

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Detalhes bibliográficos
Main Authors: Beck, Daniela, Niessner, Heike, Smalley, Keiran S.M., Flaherty, Keith, Paraiso, Kim H.T., Busch, Christian, Sinnberg, Tobias, Vasseur, Sophie, Iovanna, Juan Lucio, Drießen, Stefan, Stork, Björn, Wesselborg, Sebastian, Schaller, Martin, Biedermann, Tilo, Bauer, Jürgen, Lasithiotakis, Konstantinos, Weide, Benjamin, Eberle, Jürgen, Schittek, Birgit, Schadendorf, Dirk, Garbe, Claus, Kulms, Dagmar, Meier, Friedegund
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698985/
https://ncbi.nlm.nih.gov/pubmed/23362240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003057
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