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Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID

Somatic hypermutation (SHM) of Ig genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene transcription. We previously proposed that AID may associate with the RNA polymerase II (Pol). Here, to determine aspects of the transcription process required for SHM, w...

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Main Authors: Kodgire, Prashant, Mukkawar, Priyanka, Ratnam, Sarayu, Martin, Terence E., Storb, Ursula
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698518/
https://ncbi.nlm.nih.gov/pubmed/23752228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121523
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