Maps of open chromatin highlight cell type–restricted patterns of regulatory sequence variation at hematological trait loci

Nearly three-quarters of the 143 genetic signals associated with platelet and erythrocyte phenotypes identified by meta-analyses of genome-wide association (GWA) studies are located at non-protein-coding regions. Here, we assessed the role of candidate regulatory variants associated with cell type–r...

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Autori principali: Paul, Dirk S., Albers, Cornelis A., Rendon, Augusto, Voss, Katrin, Stephens, Jonathan, van der Harst, Pim, Chambers, John C., Soranzo, Nicole, Ouwehand, Willem H., Deloukas, Panos
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698506/
https://ncbi.nlm.nih.gov/pubmed/23570689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.155127.113
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