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Genetic instability at the adenine phosphoribosyltransferase locus in mouse L cells.

Resistance to adenine analogs such as 2,6-diaminopurine occurs at a rate of approximately 10(-3) per cell per generation in mouse L cells. This resistance is associated with a loss of detectable adenine phosphoribosyltransferase activity. Other genetic loci in L cells have the expected mutation freq...

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Detalhes bibliográficos
Main Authors: Tischfield, J A, Trill, J J, Lee, Y I, Coy, K, Taylor, M W
Formato: Artigo
Idioma:Inglês
Publicado em: 1982
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369783/
https://ncbi.nlm.nih.gov/pubmed/7110133
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