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Is the Nickel-Dependent Urease Complex of Cryptococcus the Pathogen’s Achilles’ Heel?

The nitrogen-scavenging enzyme urease has been coopted in a variety of pathogenic organisms as a virulence factor, most notoriously to neutralize stomach acid and establish infection by the gastric pathogen Helicobacter pylori. The opportunistic fungal pathogen Cryptococcus neoformans also utilizes...

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Detalhes bibliográficos
Main Authors: Morrow, Carl A., Fraser, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697809/
https://ncbi.nlm.nih.gov/pubmed/23800398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00408-13
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