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Tau as a therapeutic target in neurodegenerative disease
Tau is a microtubule-associated protein thought to help modulate the stability of neuronal microtubules. In tauopathies, including Alzheimer’s disease and several frontotemporal dementias, tau is abnormally modified and misfolded resulting in its disassociation from microtubules and the generation o...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3697479/ https://ncbi.nlm.nih.gov/pubmed/22790092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2012.07.001 |
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