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Tau as a therapeutic target in neurodegenerative disease

Tau is a microtubule-associated protein thought to help modulate the stability of neuronal microtubules. In tauopathies, including Alzheimer’s disease and several frontotemporal dementias, tau is abnormally modified and misfolded resulting in its disassociation from microtubules and the generation o...

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Detalhes bibliográficos
Main Authors: Himmelstein, Diana S., Ward, Sarah M., Lancia, Jody K., Patterson, Kristina R., Binder, Lester I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697479/
https://ncbi.nlm.nih.gov/pubmed/22790092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2012.07.001
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