Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo

Human rhinovirus (HRV) is the predominant cause of the common cold, but more importantly, infection may have serious repercussions in asthmatics and chronic obstructive pulmonary disorder (COPD) patients. A cell-based antiviral screen against HRV was performed with a subset of our proprietary compou...

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Detalhes bibliográficos
Main Authors: Spickler, Catherine, Lippens, Julie, Laberge, Marie-Kristine, Desmeules, Sophie, Bellavance, Édith, Garneau, Michel, Guo, Tim, Hucke, Oliver, Leyssen, Pieter, Neyts, Johan, Vaillancourt, Fréderic H., Décor, Anne, O'Meara, Jeff, Franti, Michael, Gauthier, Annick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697394/
https://ncbi.nlm.nih.gov/pubmed/23650168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00303-13
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