Staphylococcus aureus Formyl-Methionyl Transferase Mutants Demonstrate Reduced Virulence Factor Production and Pathogenicity

Inhibitors of peptide deformylase (PDF) represent a new class of antibacterial agents with a novel mechanism of action. Mutations that inactivate formyl methionyl transferase (FMT), the enzyme that formylates initiator methionyl-tRNA, lead to an alternative initiation of protein synthesis that does...

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Bibliographic Details
Main Authors: Lewandowski, Thomas, Huang, Jianzhong, Fan, Frank, Rogers, Shannon, Gentry, Daniel, Holland, Reannon, DeMarsh, Peter, Aubart, Kelly, Zalacain, Magdalena
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697361/
https://ncbi.nlm.nih.gov/pubmed/23571548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00162-13
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