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Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.
We studied the loss and stabilization of dihydrofolate reductase genes in clones of a methotrexate-resistant murine S-180 cell line. These cells contained multiple copies of the dihydrofolate reductase gene which were associated with double minute chromosomes. The growth rate of these cells in the a...
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1981
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7346713/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.1.12.1084 |
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