Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.

We studied the loss and stabilization of dihydrofolate reductase genes in clones of a methotrexate-resistant murine S-180 cell line. These cells contained multiple copies of the dihydrofolate reductase gene which were associated with double minute chromosomes. The growth rate of these cells in the a...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Kaufman, R J, Brown, P C, Schimke, R T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1981
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7346713/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.1.12.1084-1093.1981
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