Selection and Recombinant Phenotyping of a Novel CMX001 and Cidofovir Resistance Mutation in Human Cytomegalovirus

CMX001 is an orally available lipid acyclic nucleotide phosphonate that delivers high intracellular levels of cidofovir (CDV)-diphosphate and exhibits enhanced in vitro antiviral activity against a wide range of double-stranded DNA viruses, including cytomegalovirus (CMV). Mutations in the DNA polym...

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Autors principals: James, Scott H., Price, Nathan B., Hartline, Caroll B., Lanier, E. Randall, Prichard, Mark N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697342/
https://ncbi.nlm.nih.gov/pubmed/23650158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00062-13
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