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Induction of CYP2B6 and CYP3A4 by 1-Aminobenzotriazole (ABT) in Human Hepatocytes
ABT has been widely used in drug development process as an irreversible inhibitor of CYP enzymes. One potential use of ABT is to potentiate pharmacological effects of rapidly-metabolized drugs on CYP expression by inhibiting their metabolism; however, ABT’s own effects on expression of CYP enzymes h...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3697095/ https://ncbi.nlm.nih.gov/pubmed/20642445 |
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