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APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress
The base excision repair pathway is largely responsible for the repair of oxidative stress-induced DNA damage. However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress at the molecular level. Here, we provide evidence showing that hydrogen peroxide (H(2)O(2)) trigge...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696815/ https://ncbi.nlm.nih.gov/pubmed/23754435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301445110 |
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