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Filter gate closure inhibits ion but not water transport through potassium channels

The selectivity filter of K(+) channels is conserved throughout all kingdoms of life. Carbonyl groups of highly conserved amino acids point toward the lumen to act as surrogates for the water molecules of K(+) hydration. Ion conductivity is abrogated if some of these carbonyl groups flip out of the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hoomann, Torben, Jahnke, Nadin, Horner, Andreas, Keller, Sandro, Pohl, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696751/
https://ncbi.nlm.nih.gov/pubmed/23754382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304714110
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