The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

Despite therapeutic advances multiple myeloma remains largely incurable, and novel therapeutic concepts are needed. The Hsp90-chaperone is a reasonable therapeutic target, because it maintains oncogenic signaling of multiple deregulated pathways. However, in contrast to promising preclinical results...

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Detalhes bibliográficos
Main Authors: Chatterjee, Manik, Andrulis, Mindaugas, Stühmer, Thorsten, Müller, Elisabeth, Hofmann, Claudia, Steinbrunn, Torsten, Heimberger, Tanja, Schraud, Heike, Kressmann, Stefanie, Einsele, Hermann, Bargou, Ralf C.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696618/
https://ncbi.nlm.nih.gov/pubmed/23065523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.066175
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