Rare variants in single-minded 1 (SIM1) are associated with severe obesity

Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the paraventricular nucleus of the hypothalamus. Obesity has been reported in Sim1 haploinsufficient mice and in a patient with a balanced translocation disrupting SIM1. We sequenced t...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Ramachandrappa, Shwetha, Raimondo, Anne, Cali, Anna M.G., Keogh, Julia M., Henning, Elana, Saeed, Sadia, Thompson, Amanda, Garg, Sumedha, Bochukova, Elena G., Brage, Soren, Trowse, Victoria, Wheeler, Eleanor, Sullivan, Adrienne E., Dattani, Mehul, Clayton, Peter E., Datta, Vippan, Bruning, John B., Wareham, Nick J., O’Rahilly, Stephen, Peet, Daniel J., Barroso, Ines, Whitelaw, Murray L., Farooqi, I. Sadaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696558/
https://ncbi.nlm.nih.gov/pubmed/23778139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68016
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi