A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition

BACKGROUND AND PURPOSE: Corticosteroid insensitivity is a major therapeutic problem for some inflammatory diseases including chronic obstructive pulmonary disease (COPD), and it is known to be induced by reduced histone deacetylase (HDAC)-2 activities via activation of the phosphoinositide 3-kinase...

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Detalles Bibliográficos
Autores principales: Kobayashi, Y, Wada, H, Rossios, C, Takagi, D, Charron, C, Barnes, P J, Ito, K
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696326/
https://ncbi.nlm.nih.gov/pubmed/23758162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12187
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