A triple suicide gene strategy that improves therapeutic effects and incorporates multi-modality molecular imaging for monitoring gene-functions

Gene-directed enzyme prodrug therapy (GDEPT), or suicide gene therapy, has shown promise in clinical trials. In this preclinical study using stable cell lines and xenograft tumor models, we show that a triple-suicide-gene GDEPT approach produce enhanced therapeutic efficacy over previous methods. Im...

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Detalhes bibliográficos
Main Authors: Xing, Ligang, Sun, Xiaorong, Deng, Xuelong, Kotedia, Khushali, Zanzonico, Pat B., Ackerstaff, Ellen, Koutcher, Jason A., Ling, C. Clifton, Li, Gloria C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696018/
https://ncbi.nlm.nih.gov/pubmed/23722591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2013.28
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