Expression of Bifunctional Suicide Gene CDUPRT Increases Radiosensitization and Bystander Effect of 5-FC in Prostate Cancer Cells

PURPOSE: To test a hypothesis that, with 5-fluorocytosine (5-FC) treatment, the co-expression of cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) can lead to greater radiosensitization and bystander effect than CD-expression alone. METHODS AND MATERIALS: R3327-AT cell lines stably...

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Detalhes bibliográficos
Principais autores: Xing, Ligang, Sun, Xiaorong, Deng, Xuelong, Kotedia, Khushali, Urano, Muneyasu, Koutcher, Jason A., Ling, C. Clifton, Li, Gloria C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830274/
https://ncbi.nlm.nih.gov/pubmed/19433338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2009.04.003
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