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Human gamma- to beta-globin gene switching using a mini construct in transgenic mice.

The developmental regulation of the human globin genes involves a key switch from fetal (gamma-) to adult (beta-) globin gene expression. It is possible to study the mechanism of this switch by expressing the human globin genes in transgenic mice. Previous work has shown that high-level expression o...

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Détails bibliographiques
Auteurs principaux: Lloyd, J A, Krakowsky, J M, Crable, S C, Lingrel, J B
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC369598/
https://ncbi.nlm.nih.gov/pubmed/1549112
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