Kinetic Competition between Elongation Rate and Binding of NELF Controls Promoter Proximal Pausing

Pausing of RNA polymerase II (Pol II) 20-60 bp downstream of transcription start sites is a major checkpoint during transcription in animal cells. Mechanisms that control pausing are largely unknown. We developed permanganate-ChIP-seq to evaluate the state of Pol II at promoters throughout the Droso...

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Bibliographic Details
Main Authors: Li, Jian, Liu, Yingyun, Rhee, Ho Sung, Ghosh, Saikat Kumar B., Bai, Lu, Pugh, B. Franklin, Gilmour, David S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695833/
https://ncbi.nlm.nih.gov/pubmed/23746353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.016
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