NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly

The Negative Elongation Factor (NELF) is a transcription regulatory complex that induces stalling of RNA polymerase II (Pol II) during early transcription elongation and represses expression of several genes studied to date, including Drosophila Hsp70, mammalian proto-oncogene junB, and HIV RNA. To...

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Detalhes bibliográficos
Main Authors: Gilchrist, Daniel A., Nechaev, Sergei, Lee, Chanhyo, Ghosh, Saikat Kumar B., Collins, Jennifer B., Li, Leping, Gilmour, David S., Adelman, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492738/
https://ncbi.nlm.nih.gov/pubmed/18628398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1643208
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