The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

BACKGROUND: Expression of the cellular karyopherin TNPO3/transportin-SR2/Tnp3 is necessary for HIV-1 infection. Depletion of TNPO3 expression in mammalian cells inhibits HIV-1 infection after reverse transcription but prior to integration. RESULTS: This work explores the role of cleavage and polyade...

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Autors principals: Fricke, Thomas, Valle-Casuso, Jose Carlos, White, Tommy E, Brandariz-Nuñez, Alberto, Bosche, William J, Reszka, Natalia, Gorelick, Robert, Diaz-Griffero, Felipe
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695788/
https://ncbi.nlm.nih.gov/pubmed/23622145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-46
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