TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found th...

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Autors principals: Valle-Casuso, Jose Carlos, Di Nunzio, Francesca, Yang, Yang, Reszka, Natalia, Lienlaf, Maritza, Arhel, Nathalie, Perez, Patricio, Brass, Abraham L., Diaz-Griffero, Felipe
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347269/
https://ncbi.nlm.nih.gov/pubmed/22398280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00451-12
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