Chk2 PHOSPHORYLATION OF SURVIVIN-ΔEx3 CONTRIBUTES TO A DNA DAMAGE-SENSING CHECKPOINT IN CANCER

Survivin is an oncogene that functions in cancer cell cytoprotection and mitosis. Here we report that differential expression in cancer cells of a C-terminal splice variant of survivin, termed survivin-ΔEx3, is tightly associated with aggressive disease and markers of unfavorable prognosis. In contr...

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Autors principals: Lopergolo, Alessia, Tavecchio, Michele, Lisanti, Sofia, Ghosh, Jagadish C., Dohi, Takehiko, Faversani, Alice, Vaira, Valentina, Bosari, Silvano, Tanigawa, Nobuhiko, Delia, Domenico, Kossenkov, Andrew V., Showe, Louise C., Altieri, Dario C.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695608/
https://ncbi.nlm.nih.gov/pubmed/22586065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4035
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