Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi

Approximately 10% of melanoma cases are familial, but only 25–40% of familial melanoma cases can be attributed to germ-line mutations in the CDKN2A – the most significant high-risk melanoma susceptibility locus identified to date. The pathogenic mutation(s) in most of the remaining familial melanoma...

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Bibliographic Details
Main Authors: Hawkes, Jason E., Campbell, Jennifer, Garvin, Daniel, Cannon-Albright, Lisa, Cassidy, Pamela, Leachman, Sancy A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695489/
https://ncbi.nlm.nih.gov/pubmed/23825798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00160
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