Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi

BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures and lead to constitutive activation of the MAP-kinase pathway1, 2. However, BRAF and NRAS mutations are absent in a number of other melanocytic neopl...

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Main Authors: Van Raamsdonk, Catherine D., Bezrookove, Vladimir, Green, Gary, Bauer, Jürgen, Gaugler, Lona, O’Brien, Joan M., Simpson, Elizabeth M., Barsh, Gregory S., Bastian, Boris C.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696133/
https://ncbi.nlm.nih.gov/pubmed/19078957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07586
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