Dopamine Release Suppression Dependent on an Increase of Intracellular Ca(2+) Contributed to Rotenone-induced Neurotoxicity in PC12 Cells

Rotenone is an inhibitor of mitochondrial complex I that produces a model of Parkinson’s disease (PD), in which neurons undergo dopamine release dysfunction and other features. In neurons, exocytosis is one of the processes associated with dopamine release and is dependent on Ca(2+) dynamic changes...

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Detalhes bibliográficos
Main Authors: Sai, Yan, Chen, Junfeng, Ye, Feng, Zhao, Yuanpeng, Zou, Zhongmin, Cao, Jia, Dong, Zhaojun
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society of Toxicologic Pathology 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695337/
https://ncbi.nlm.nih.gov/pubmed/23914057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.26.149
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