Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells

G protein-coupled receptor 3 (GPR3) is a constitutively active receptor that maintains high 3′-5′-cyclic adenosine monophosphate (cAMP) levels required for meiotic arrest in oocytes and CNS function. Ligand-activated G protein-coupled receptors (GPCRs) signal at the cell surface and are silenced by...

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Bibliografiska uppgifter
Huvudupphovsmän: Lowther, Katie M., Uliasz, Tracy F., Götz, Konrad R., Nikolaev, Viacheslav O., Mehlmann, Lisa M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694969/
https://ncbi.nlm.nih.gov/pubmed/23826079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065365
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