Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

Most G protein-coupled receptors (GPCRs) recruit β-arrestins and internalize upon agonist stimulation. For the μ-opioid receptor (μ-OR), this process has been linked to development of opioid tolerance. GPCR kinases (GRKs), particularly GRK2 and GRK3, have been shown to be important for μ-OR recruitm...

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Publicado en:Sci Rep
Autores principales: Møller, Thor C., Pedersen, Mie F., van Senten, Jeffrey R., Seiersen, Sofie D., Mathiesen, Jesper M., Bouvier, Michel, Bräuner-Osborne, Hans
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567791/
https://ncbi.nlm.nih.gov/pubmed/33060647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73674-0
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