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MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity
MDM2 plays a crucial role in negatively regulating the functions of tumor suppressor p53. Here we show that MDM2 can inhibit Axin-stimulated p53-dependent apoptosis by suppressing p53 phosphorylation at Ser 46 and apoptosis-related p53 transactivational activity. Interestingly, the ubiquitin E3 liga...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694902/ https://ncbi.nlm.nih.gov/pubmed/23826318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067529 |
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