Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain-interacting protein kinase-2 (HIPK2), which is linked to UV-induced p53-dependent apoptosis by interacting with, and phosphorylating Ser 46 of, p53. In addition to as...

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Bibliografski detalji
Glavni autori: Rui, Yanning, Xu, Zhen, Lin, Shuyong, Li, Qinxi, Rui, Hongliang, Luo, Wen, Zhou, Hai-Meng, Cheung, Po-Yan, Wu, Zhenguo, Ye, Zhiyun, Li, Peng, Han, Jiahuai, Lin, Sheng-Cai
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC533058/
https://ncbi.nlm.nih.gov/pubmed/15526030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600475
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