DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

DNA methylation changes dynamically during development and is essential for embryogenesis in mammals. However, how DNA methylation affects developmental gene expression and cell differentiation remains elusive. During embryogenesis, many key transcription factors are used repeatedly, triggering diff...

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Detalhes bibliográficos
Main Authors: Oda, Masaaki, Kumaki, Yuichi, Shigeta, Masaki, Jakt, Lars Martin, Matsuoka, Chisa, Yamagiwa, Akiko, Niwa, Hitoshi, Okano, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694845/
https://ncbi.nlm.nih.gov/pubmed/23825962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003574
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