DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

DNA methylation changes dynamically during development and is essential for embryogenesis in mammals. However, how DNA methylation affects developmental gene expression and cell differentiation remains elusive. During embryogenesis, many key transcription factors are used repeatedly, triggering diff...

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Autori principali: Oda, Masaaki, Kumaki, Yuichi, Shigeta, Masaki, Jakt, Lars Martin, Matsuoka, Chisa, Yamagiwa, Akiko, Niwa, Hitoshi, Okano, Masaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694845/
https://ncbi.nlm.nih.gov/pubmed/23825962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003574
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